Quantification of cerebellar hemispheric purkinje cell linear density: 32 ET cases versus 16 controls
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چکیده
منابع مشابه
Feedforward inhibition controls the spread of granule cell-induced Purkinje cell activity in the cerebellar cortex.
Synapses associated with the parallel fiber (pf) axons of cerebellar granule cells constitute the largest excitatory input onto Purkinje cells (PCs). Although most theories of cerebellar function assume these synapses produce an excitatory sequential "beamlike" activation of PCs, numerous physiological studies have failed to find such beams. Using a computer model of the cerebellar cortex we pr...
متن کاملThe linear computational algorithm of cerebellar Purkinje cells.
The orchestration of simple motor tasks by the cerebellum results in coordinated movement and the maintenance of balance. The cerebellum integrates sensory and cortical information to generate the signals required for the coordinated execution of simple motor tasks. These signals originate in the firing rate of Purkinje cells, each of which integrates sensory and cortical information conveyed b...
متن کاملOleuropein Attenuates Deltamethrin-induced Apoptosis in Rat Cerebellar Purkinje Neurons
Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. This study aimed at determining the DM toxicity and anti-apoptotic effect of OE pretreatment in cerebellar Purkinje neurons. Materials and Methods: Rats were randomly divided into four groups a...
متن کاملReduced Purkinje cell number in essential tremor: a postmortem study.
BACKGROUND Clinical and functional imaging evidence suggests that cerebellar dysfunction occurs in essential tremor (ET). In recent postmortem studies, we documented increased numbers of torpedoes (Purkinje cell axonal swellings) in ET patients without Lewy bodies. Purkinje cell loss, however, has never been rigorously assessed. OBJECTIVE To quantitatively assess the number of Purkinje cells ...
متن کاملCurrent source density correlates of cerebellar Golgi and Purkinje cell responses to tactile input.
The overall circuitry of the cerebellar cortex has been known for over a century, but the function of many synaptic connections remains poorly characterized in vivo. We used a one-dimensional multielectrode probe to estimate the current source density (CSD) of Crus IIa in response to perioral tactile stimuli in anesthetized rats and to correlate current sinks and sources to changes in the spike...
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ژورنال
عنوان ژورنال: Movement Disorders
سال: 2013
ISSN: 0885-3185
DOI: 10.1002/mds.25629